Detection of SARS-CoV-2 in aerosols in long term care facilities and other indoor spaces with known COVID-19 outbreaks.

Coronavirus outbreaks are likely to occur in crowded and congregate indoor spaces, and their effects are most severe in vulnerable long term care facilities (LTCFs) residents. Public health officers benefit from tools that allow them to control COVID-19 outbreaks in vulnerable settings such as LTCFs, but which could be translated in the future to control other known and future virus outbreaks. This study aims to develop and test a methodology based on detection of SARS-CoV-2 in aerosol samples collected with personal pumps that could be easily implemented by public health officers. The proposed methodology was used to investigate the levels of SARS-CoV-2 in aerosol in indoor settings, mainly focusing on LTCFs, suffering COVID-19 outbreaks, or in the presence of known COVID-19 cases, and targeting the initial days after diagnosis. Aerosol samples (N = 18) were collected between November 2020 and March 2022 in Castelló (Spain) from LTCFs, merchant ships and a private home with recently infected COVID-19 cases. Sampling was performed for 24-h, onto 47 mm polytetrafluoroethylene (PTFE) and quartz filters, connected to personal pumps at 2 and 4 L/min respectively. RNA from filters was extracted and SARS-CoV-2 was determined by detection of regions N1 and N2 of the nucleocapsid gene alongside the E gene using RT-PCR technique. SARS-CoV-2 genetic material was detected in 87.5% samples. Concentrations ranged ND-19,525 gc/m3 (gene E). No genetic traces were detected in rooms from contacts that were isolated as a preventative measure. Very high levels were also measured at locations with poor ventilation. Aerosol measurement conducted with the proposed methodology provided useful information to public health officers and contributed to manage and control 12 different COVID-19 outbreaks. SARS-CoV-2 was detected in aerosol samples collected during outbreaks in congregate spaces. Indoor aerosol sampling is a useful tool in the early detection and management of COVID-19 outbreaks and supports epidemiological investigations.

Terapia fotodinámica con luz de día en el tratamiento de la queilitis actínica / Actinic Cheilitis Treated With Daylight Photodynamic Therapy

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Vulnerability of a top marine predator to coastal storms: a relationship between hydrodynamic drivers and stranding rates of newborn pinnipeds.

Coastal storms have increased in recent decades, affecting many species, including the South American sea lion (Otaria byronia). Reports of stranded sea lion pups are becoming common in Chile, presumably due to the increase in the frequency and intensity of coastal storms. To validate this assumption, a 10-year database was built by coupling wave generation and coastal propagation models to correlate pure wave parameters (significant wave height Hs, peak period Tp, normalized wave power Hs2 Tp) and wave parameters including the tidal level (maximum surface elevation η, modified wave power η2 Tp) with records of stranded pups in Cobquecura, the largest breeding colony in central Chile. The correlation between the number of pups stranded per day and wave parameters in the first half of January and the last half of February is poor, while they are stronger for the second half of January and the first half of February. The higher number of stranded pups coincide with coastal storms with normalized wave power values exceeding a threshold of 100 m2/s. Conversely, below this threshold there is wide dispersion between the number of strandings and wave parameters. Identifying wave parameter thresholds could be used to predict when newborn pups will be most affected by coastal storms, and thus help institutions to develop remediation techniques for animals at risk.

Mortality Rates of Patients with Proximal Femoral Fracture in a Worldwide Pandemic: Preliminary Results of the Spanish HIP-COVID Observational Study.

BACKGROUND: The outbreak of coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), in December 2019 in Wuhan, People's Republic of China, has developed into an unprecedented pandemic with enormous pressure on health-care providers around the world. A higher mortality rate has been described in older infected individuals. Patients with hip fracture are a particularly vulnerable population during this pandemic because older age is associated with a higher mortality rate. Our aim was to describe the early mortality rate and demographic variables in a hip fracture sample population in Spain during the coronavirus pandemic. METHODS: This is a multicenter, observational, retrospective, descriptive study. We collected data from 13 major hospitals in Spain from the beginning of the national state of alarm (declared on March 14, 2020, by the Spanish government) until the end of our study period on April 4, 2020. All patients who were ≥65 years of age, presented to the Emergency Department of the participating hospitals during this period with a diagnosis of proximal femoral fracture, and had a minimum follow-up of 10 days were included in the cohort. In addition to mortality, demographic and other potential prognostic variables were also collected. RESULTS: In this study, 136 patients with a hip fracture were included. Of these patients, 124 underwent a surgical procedure and 12 were managed nonoperatively. The total mortality rate was 9.6%. Sixty-two patients were tested for COVID-19, with 23 patients being positive. The mortality rate for these 23 patients was 30.4% (7 of 23 patients) at a mean follow-up of 14 days. The mortality rate was 10.3% (4 of 39) for patients who had been tested and had a negative result and 2.7% (2 of 74) for patients who had not been tested. Of the 12 patients who were managed nonoperatively, 8 (67%) died, whereas, of the 124 patients who were surgically treated, 5 (4%) died. Results differed among centers. CONCLUSIONS: There is a higher mortality rate in patients with a hip fracture and an associated positive test for COVID-19. LEVEL OF EVIDENCE: Prognostic Level IV. See Instructions for Authors for a complete description of levels of evidence.

Calidad de vida en pacientes con linfomas cutáneos de células T / Quality of Life in Patients with Cutaneous T-Cell Lymphoma

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Community strengthening and mental health system linking after flooding in two informal human settlements in Peru: a model for small-scale disaster response.

BACKGROUND: Mental health is an important factor in responding to natural disasters. Observations of unmet mental health needs motivated the subsequent development of a community-based mental health intervention following one such disaster affecting Peru in 2017. METHODS: Two informal human settlements on the outskirts of Lima were selected for a mental health intervention that included: (1) screening for depression and domestic violence, (2) children's activities to strengthen social and emotional skills and diminish stress, (3) participatory theater activities to support conflict resolution and community resilience, and (4) community health worker (CHW) accompaniment to government health services. RESULTS: A total of 129 people were screened across both conditions, of whom 12/116 (10%) presented with depression and 21/58 (36%) reported domestic violence. 27 unique individuals were identified with at least one problem. Thirteen people (48%) initially accepted CHW accompaniment to government-provided services. CONCLUSIONS: This intervention provides a model for a small-scale response to disasters that can effectively and acceptably identify individuals in need of mental health services and link them to a health system that may otherwise remain inaccessible.

Extirpación eco-guiada mínimamente invasiva del tumor glómico digital / Ultrasound-Guided, Minimally Invasive Resection of a Digital Glomus Tumor

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Haploidentical IL-15/41BBL activated and expanded natural killer cell infusion therapy after salvage chemotherapy in children with relapsed and refractory leukemia.

Primary refractory or relapsed pediatric leukemia yield significant morbidity and mortality, with long-term survival rates <40%. Here we present a post-hoc analysis assessing safety and efficacy of infusing activated and expanded Natural Killer cells (NKAE) from haploidentical donors in patients from 2 clinical trials. In total, 18 children, adolescents and young adults with relapse or refractory acute leukemia were treated with two cycles of rescue chemotherapy followed by fresh NKAE cells infusions and low doses of IL-2. The overall response rate, complete remission achievement at the end of the study, was 72% (13 of 18). We infused 52 NKAE cell products containing a median of 6.76 × 106 NK cells/kg (0.7-34.16) and 0.49 × 106 T cells/kg (0-11). All infusions were well tolerated with no graft versus host disease nor other serious adverse events. Among the 14 patients who completed treatment, 4 of them are alive and leukemia-free more than 750 days post-transplant. We conclude that infusion of fresh NKAE cell therapy is feasible and safe in heavily pretreated pediatric population, and should be further investigated in advanced-phase clinical trials as well as a consolidation therapy to decrease relapse in patients with high-risk leukemia. TRIALS REGISTRATION: Registered at www.clinicaltrials.gov as NCT01944982 and NCT02074657.

Dermatitis granulomatosa postherpética en un paciente tratado con nivolumab / Postherpetic Granulomatous Dermatitis in a Man Treated With Nivolumab

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Foros virtuales y construcción de conocimiento en profesionales de la salud / Virtual forums and knowledge building among health professionals / Foros virtuais e construção de conhecimento em professionais da saúde

La modalidad e-learning se ha convertido en un método que ha permitido a los profesionales de la salud actualizar sus conocimientos. Esta forma de enseñanza facilita la construcción de aprendizaje colaborativo entre quienes participan en foros de discusión. Objetivo: Describir la construcción de conocimiento colaborativo de profesionales de la salud de las comunidades virtuales de aprendizaje que participan en cursos del Programa de Educación Continua de la Escuela de Enfermería de la Universidad Católica de Chile en 2014. Método: Estudio mixto cuantitativo descriptivo y cualitativo con análisis de contenido según Earl Babbie y basado en el modelo de Gunawardena. Resultados: La construcción de conocimiento se realiza, predominantemente, en las fases I y II del modelo de Gunawardena. Conclusión: Si bien los foros permiten la construcción de conocimiento colaborativo, en áreas específicas del saber, al igual que algunos otros estudios reportados en la literatura, el conocimiento alcanza solo las primeras etapas del modelo de Gunawardena, que implicaría que comparten información y establecen desacuerdos entre los argumentos, pero no se lograría un mayor aprendizaje, es decir, generan una propuesta con las ideas del grupo, contrastan lo discutido con la experiencia personal o información existente, sin embargo no aplican los nuevos conocimientos construidos.

E-learning modality has become a method which has allowed health professionals to update their knowledge. It is a teaching strategy which facilitates the collaborative knowledge building among those participating in the discussion forums. Objective: To describe collaborative knowledge building among health professionals in learning virtual communities who participate in courses of the Continuous Education Program of the Nursing School of the Catholic University of Chile in 2014. Method: This is a quantitative, descriptive, and qualitative study with content analysis following the guidelines of Earl Babbie and based on the Gunawardena model. Results: Knowledge building takes place, mainly, in stages II and II of the Gunawardena model. Conclusion: While these forums allow the building of collaborative knowledge in some specifiareas, as it was reported in other studies, this knowledge only reaches the first stages of the Gunawardena model, which means that there is information sharing, and arguments are agreed or disagreed, but there is no further learning; in other words, the proposed group's ideas contrast the discussions around personal experiences or existing knowledge, however, the new built knowledge is not applied.

Resumo: A modalidade e-learning tornou-se em um método que permitiu aos profissionais da saúde atualizar seus conhecimentos. Esta forma de ensino facilita a construção de aprendizagem colaborativa entre quem participa em foros de discussão. Objetivo: Descrever a construção de conhecimento colaborativo de profissionais da saúde das comunidades virtuais de aprendizagem que participam em cursos do Programa de Educação Continuada da Escola de Enfermagem da Universidade Católica do Chile em 2014. Método: Estudo misto quantitativo descritivo e qualitativo com análise de conteúdo segundo Earl Babbie e baseado no modelo de Gunawardena. Resultados: A construção de conhecimento realiza-se, predominantemente, nas fase I e II modelo de Gunawardena. Conclusão: Se bem os foros permitem a construção de conhecimento colaborativo, em áreas específicas do saber, ao igual que alguns outros estudos reportados na literatura, o conhecimento só atinge as primeiras etapas do modelo de Gunawardena, que implicaria que compartilham informação e estabelecem desacordos entre os argumentos, mas não se consegue uma maior aprendizagem, quer dizer, geram uma proposta com as ideias do grupo, contrastam o discutido com a experiência pessoal ou informação existente, no entanto, não aplicam os novos conhecimentos construídos.

FR-Traumatismos repetitivos y melanoma acral plantar / RF-acral melanoma and repetitive injury to the sole of the foot

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FR- Exposición solar insuficiente y mortalidad global: ¿debemos recomendar o desaconsejar la exposición solar a nuestros pacientes? / RF- insufficient exposure to sunlight and global mortality: should we advise against or recommend sun exposure?

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Determination of the optimal tolerance for MLC positioning in sliding window and VMAT techniques.

PURPOSE: Several authors have recommended a 2 mm tolerance for multileaf collimator (MLC) positioning in sliding window treatments. In volumetric modulated arc therapy (VMAT) treatments, however, the optimal tolerance for MLC positioning remains unknown. In this paper, the authors present the results of a multicenter study to determine the optimal tolerance for both techniques. METHODS: The procedure used is based on dynalog file analysis. The study was carried out using seven Varian linear accelerators from five different centers. Dynalogs were collected from over 100,000 clinical treatments and in-house software was used to compute the number of tolerance faults as a function of the user-defined tolerance. Thus, the optimal value for this tolerance, defined as the lowest achievable value, was investigated. RESULTS: Dynalog files accurately predict the number of tolerance faults as a function of the tolerance value, especially for low fault incidences. All MLCs behaved similarly and the Millennium120 and the HD120 models yielded comparable results. In sliding window techniques, the number of beams with an incidence of hold-offs >1% rapidly decreases for a tolerance of 1.5 mm. In VMAT techniques, the number of tolerance faults sharply drops for tolerances around 2 mm. For a tolerance of 2.5 mm, less than 0.1% of the VMAT arcs presented tolerance faults. CONCLUSIONS: Dynalog analysis provides a feasible method for investigating the optimal tolerance for MLC positioning in dynamic fields. In sliding window treatments, the tolerance of 2 mm was found to be adequate, although it can be reduced to 1.5 mm. In VMAT treatments, the typically used 5 mm tolerance is excessively high. Instead, a tolerance of 2.5 mm is recommended.